Pseudoprogression pd 1

抗PD-1療法は、画像上のpseudoprogressionを含む、従来見られなかった奏効パターンを来すことがある。今回は、進行非小細胞肺癌におけるpseudoprogressionの実臨床での発生率を調べ、奏効に関する評価基準による比較を行っ Pseudoprogression in immune checkpoint inhibitor therapy was initially found in melanoma, at first in the research of the anti-CTLA4 inhibitor ipilimumab [] and then in the studies of anti-PD-1 therapies, pembrolizumab and] その勢いを実感しました。とはいえ、免疫療法に隅から隅まで関心が寄せられているわけではないようです。やはり主役は、抗PD-1抗体、抗PD-L1抗体、抗CTLA4抗体などのチェックポイント阻害。細胞移植のような発表になると一気に聴 Pseudoprogression has also been pointed out in patients with MSI tumors treated with anti‐PD(L)‐1 agents. 25 Overall, this event does not exceed 10% independent of tumor type. Interestingly, the two patients presenting a PSP

PD-1 SLAMF7 STING TIGIT TIM-3 腫瘍溶解性ウイルス 免疫経路の組み合わせと免疫応答の長期持続性 I-Oの基本事項 免疫学の基本事項 I-O Biomarkers がん抗原 ネオアンチゲン TMB MSI-H/dMMR 免疫抑制マーカー LAG-3 Treg Pseudoprogression: Pseudoprogression of a cancer refers to an increase in the size of a tumor or number of metastases on imaging tests, that is not due to the growth or spread of the cancer. Unfortunately, while there are tests that may help predict who will best respond to these drugs, there aren't any objective ways at this time to predict who may develop hyperprogression or pseudoprogression PD-1/PD-L1阻害薬治療直後の6週間以内にHPDになった場合、PDと比較しても有意に全生存期間が短かった(3.4ヶ月[2.8-7.5] vs, 6.2ヶ月[5.3-7.9]、ハザード比2.18 [1.29-3.69]、P=0.003)。一方化学療法を受けた患者59人のうち3人(

Pseudoprogressionは多くない。 - 肺癌を勉強するブロ

  1. Three retrospective studies on the matter have reported a pseudoprogression rate of 7% in melanoma. 1-3 The incidence of pseudoprogression in epithelial malignancies such as non-small cell lung cancer (NSCLC) and urothelial carcinoma has been reported at a much lower rate of 1.5 - 3.0%.3 A recent retrospective French study reported pseudoprogression in 4.7% of patients with NSCLC treated with PD1 or PDL1 inhibitors. 4 Attempts to elucidate which patients are more likely to experience a pseudoprogression event have rendered inconclusive results
  2. 抗 PD-1 抗体 Pembrolizumab 治療例の治療効果判定: RECIST v1.1/ immune-related response criteria (irRC) 画像上の「進行」がみられた後の経過について、さらに詳細に(型を決めて)画像評価を継続すること自体、Pseudoprogression という概念があって初めて計画されえたものだといえる
  3. オーストラリアMacquarie UniversityのLeeらは、PD-1抗体薬による治療を受ける進行悪性黒色腫患者 (n=125)において、ベースライン時・治療12週目の血中循環腫瘍DNA (ctDNA)がpseudoprogressionと真の進行を弁別可能か検討した
  4. Radiologic Pseudoprogression during Anti-PD-1 Therapy for Advanced Non-Small Cell Lung Cancer Author links open overlay panel Sharyn I. Katz MD, MTR a Mark Hammer MD a b Stephen J. Bagley MD c Charu Aggarwal MD,.
  5. 免疫チェックポイント阻害薬 (抗 PD-1 抗体薬/抗 PD-L1 抗体薬)とは、がん細胞を攻撃する T細胞 の働きにブレーキをかけている蛋白質であるPD-1とPD-L1の結合を阻止することで、PD-L1により抑えられていたT細胞の働きを活性化することで抗腫瘍効果を発揮させる薬である
  6. PD-1による抑制はT細胞に対して直接発揮されると考えられていましたが、T細胞を作れないマウスを用いた実験系によって、T細胞の分化を間接的に支配する自然免疫系をも抑制することがわかりました(図4)。PD-1は、自己組織に対す
(PDF) Pseudoprogression on PSMA PET imaging of a mCRPCImmuno-oncology Trial Endpoints: Capturing ClinicallyMechanism of action of nivolumab

Pseudoprogression and hyperprogression after checkpoint

  1. するpseudoprogression(偽進行)が起きることがある. 今回我々は,ニボルマブ治療にて進行(progressive disease;PD)したものの,その後半年の経過で部分奏効 (partialresponse;PR)となったpseudoprogressionの 1例を経験
  2. Thus, a high percentage of PD-1 + CD8 + and HLA-DR + CD8 + T cells might represent a biomarker for ascitic fluid pseudoprogression after immune checkpoint therapy. It is possible that the development of ascites was secondary to a non-specific immune-related adverse event such as autoimmune peritonitis
  3. PD-1(抗プログラム死1)という名前から分かる通り、PD-1はT細胞などによるプログラム死に抵抗する働きがあります。さらに、がん細胞には、PD-L1やPD-L2と呼ばれる「PD-1と結合するための受容体」が存在します。これらが結合するこ
  4. 6580 Background: Pseudoprogression (PP), tumor growth from treatment effect rather than true disease progression, has been described with immune checkpoint inhibitors. Our study measures rates and time course of PP and associated patient outcomes using RECIST 1.1 and irRC criteria. Methods: Cohort was retrospectively drawn from subjects enrolled in phase I and II trials from March 2008 to July.
  5. PD-1抗体は即効性があ まりなく、効いてくるまで6-12 週かかります。 即効性の指標の一つとなる奏効率では ニボルマブやペムブロリズマブで20-40%、イピリムマブは10-20%です
  6. PD-1 TIM-3 CCR2/5 EP4 KIR SLAMF7 CD73 ICOS LAG-3 STING Combinations & Long-Term Immunity Essentials of I-O Essentials of Immunology I-O Biomarkers Tumor Antigens Neoantigens TMB MSI-H/dMMR LAG-3 Tregs.
  7. The results demonstrate that ctDNA profiles can accurately differentiate pseudoprogression from true progression of disease in patients with melanoma treated with PD-1 antibodies. Results of this blood test performed at regula

Multiple recent clinical trials using antibodies to PD-1 and PD-L1 in the treatment of advanced solid tumors have been completed and published,10-22enabling broader evaluation of pseudoprogression across solid tumors Pseudoprogression refers to a specific pattern of response sometimes observed in malignant melanoma patients receiving treatment with immune-checkpoint inhibitors. Although cases with pseudoprogression documented once have been reported previously, there have been no case reports yet of pseudoprogression events documented twice during treatment. A 55-year-old man underwent surgery for locally. No difference was observed between anti-PD-1 and anti-PD-L1 across the different histologies, the number of metastasis, the tumor burden, the number and type of previous treatments. An association between HPD and older age has been observed, with a median age of 65.5 years for HPD patients vs. 55 years for non-HPD (P=0.007) Pseudoprogressionは治療後に一時的な腫瘊増大をみる非典型的な現象である。従来は,脳腫瘊などに放射線・抗癌剤治療を併用した際に生じることが報告されていたが,同様の現象が免疫チェックポイント阻害剤使用後にも生じ,その本体は,Tリンパ球の集簇と腫瘊壊死であると報告されている Hyperprogression and pseudoprogression appear to be response patterns that are specific to immunotherapy with inhibitors of PD-1 and PD-L1. medwireNews: Hyperprogression and pseudoprogression appear to be response patterns that are specific to immunotherapy with inhibitors of programmed cell death protein 1 (PD-1) and its ligand (PD-L1) in patients with non-small-cell lung cancer, say researchers

#4001:胃癌に対するPembrolizumab 進行胃癌に抗PD-1抗体薬Pembrolizumabを投与した際のPD-L1発現と予後の関連性を検討 室:次は胃癌です。川崎先生お願いします。 川崎:ESMO2014と2015年消化器癌シンポジウムで室先生が発表されたKEYNOTE-012試験の追加報告です るPD-1やPD-L1というものがあるよ うですが、どのようなものなのでしょ うか。 清家 ヒトの免疫は樹状細胞ががん 細胞を認識してリンパ球を活性化し、 リンパ球ががんを攻撃しなさいと指示 するかたちで免疫能が働いているので すが.

PD-1抗体およびPD-L1抗体の作用機序 ・抗腫瘍活性をもつTリンパ球に表面には PD-1分子が発現しており、これが腫瘍表面 のPD-L1もしくはPD-L2と結びつくと、活性が 落ちる。 ・PD-1受容体などを抗体でブロックすること により、この. Pseudoprogression remains a rare event with PD-1 blockade. In the seminal phase I trial of nivolumab, only 4.6% of NSCLC patients had unconventional responses; mostly emergence of new lesions coupled with. We aimed at characterizing pseudoprogression (PSPD) among patients with various solid tumor types treated by anti-PD(L)-1. METHODS All consecutive patients (pts) enrolled in phase 1 trials with advanced solid tumors and lymphomas treated in phase I clinical trials evaluating monotherapy by anti-PD(L)-1 at Gustave Roussy were analyzed

チェックポイント阻害とPseudo progression【日経バイオテク

Evidence of pseudoprogression in patients treated with PD1

Pseudoprogression presenting as intestinal perforation in non-small cell lung cancer treated with anti-PD-1: A case report Hee Kyung Kim , 1 Seung-Woo Baek , 1 Yusook Jeong , 1 Yaewon Yang , 1 Jihyun Kwon , 1 Hye Sook Han , 1, 2 Jin-Young An , 2, 3 Chang Gok Woo , 4 Ok-Jun Lee , 2, 4 Taek Gu Lee , 2, 5 and Ki Hyeong Lee 1, Pseudoprogression and Radiosurgery in Combination with ICI The occurrence of pseudoprogression after radiosurgery in combination with ICI therapy has so far not been well recognized. Compared with radiation necrosis, pseudoprogression may differ in terms of the time course of development (typically earlier) and the tissue reactions involved 抗PD-1抗体 ニボルマブ(オプジーボ) 悪性黒色腫(メラノーマ) 術後補助療法。根治切除不能例では、イピリムマブを併用可 肺がん 切除不能な進行・再発の非小細胞肺がん 腎細胞がん 根治切除不能、または転移性の腎細胞がん In our study, pseudoprogression corresponded to one‐third of all patients who had PD according to Response Evaluation Criteria in Solid Tumors, version 1.1, and these patients had similar OS compared with nonprogressors. Th

References 1. Kurra V, Sullivan RJ, et al. Pseudoprogression in cancer immunotherapy: rates, time course and patient outcomes. J Clin Oncol 34, 2016 (suppl; abstr 6580). 2. Lee JH, Long GV, Menzies AM, et al. Immunotherapies targeting the PD-1 checkpoint pathway have recently gained regulatory approval in numerous cancer types. With the widespread use of immune checkpoint therapies, varying patterns of responses and immune-related adverse events are being observed. In this case, we highlight a patient who developed recurrent, large-volume ascites, while simultaneously having a 49% reduction in. Background: PD(L)1 antibodies (anti-PD(L)-1) have been a major breakthrough in several types of cancer. Novel patterns of response and progression have been described with anti-PD(L)-1. We aimed at characterizin A small subset of patients treated with immune checkpoint inhibitors manifest atypical patterns of response, the so-called pseudoprogression (PP) and hyperprogression (HP). Their prevalence in urothelial (UC) and renal cancer (RCC) remains, to date, mostly uninvestigated. Therefore, we aimed to provide a summary of the current knowledge about PP and HP during immune checkpoint inhibitor.

Pseudoprogression, a response that occurs after the initial development of new lesions or an increase in the size of target lesions, occurs in up to 10% of patients treated with PD-1 antibodies. 5 Confirmation of pseudoprogression 1. Cancer Med. 2020 Feb 19. doi: 10.1002/cam4.2797. [Epub ahead of print] Evidence of pseudoprogression in patients treated with PD1/PDL1 antibodies across tumor types. Martin-Romano P(1), Castanon E(2), Ammari.

(PDF) Evidence of pseudoprogression in patients treated

Kim HK, Baek SW, Jeong Y, et al. Pseudoprogression presenting as intestinal perforation in non-small cell lung cancer treated with anti-PD-1: A case report. Mol Clin Oncol. 2019;11:132-4. Mol Clin Oncol. 2019;11:132-4 PD-1は、活性化した細胞傷害性T細胞の表面に発現する抑制性の免疫チェックポイント受容体です 1,2。 PD-L2は、がん細胞を含む様々な細胞で発現します 1,2。 PD-L2のPD-1に対する親和性はPD-L1より高いものの、その発現量はPD-L 終末期 (1) 脳イメージング研究 (2) 法律について (0) その他 (4) 日常生活動作 ADL (5) 生活の質 QOL (1) 家族について (2) 海外のホームページ (2) 日本のホームページ (14) 筋力について (3) 認知機能について (14) 症例報告 (3) 日 Site‐specific response patterns, pseudoprogression, and acquired resistance in patients with melanoma treated with ipilimumab combined with anti-PD‐1 therapy Melanoma Institute Australia, Sydney, New South Wale

death-1 (PD-1) or its ligand (PD-L1) have become an important treatment option for non-small cell lung cancer (NSCLC).1 Recently, pembrolizumab, nivolumab, and atezolizumab have documented overall survival Saâda-Bouzid E, Defaucheux C, Karabajakian A, et al. Hyperprogression during anti-PD-1/PD-L1 therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol 2017; 28: 1605-1611 Pseudoprogression, a response that occurs after the initial development of new lesions or an increase in the size of target lesions, occurs in up to 10% of patients treated with PD-1 antibodies, wrote study authors led by Jenny Previous Article Effectiveness of anti-PD-1 for hepatocellular carcinoma Next Article Top ten research priorities for pancreatic cancer therapy Rui Liao suggested that the three patients who had at least a 50% increase in target lesion size at their first response evaluation but showed tumour shrinkage at subsequent assessments actually had pseudoprogression rather than hyperprogression 最近、抗PD-1抗体または抗PD-L1抗体が投与されたがん患者において、急速な腫瘍増大(Hyperprogressive disease ;HPD) が散見され、新しい増悪パターンとして注目されている。 今回の報告は、フランスで行われた多施設後ろ向き研究で、対象は進行非小細胞肺がん(NSCLC)患者で抗PD-1抗体または抗PD-L1.

Pseudo-progressionとI-O がん免疫

Nivolumab binds to PD-1 and blocks its interaction with the PD-L1 ligand, which restores the antitumour immunity (B). Example of repeated tumour pseudoprogression 抗PD-1/PD-L1抗体薬治療歴のある進行性非小細胞肺がん患者において急速な腫瘍増大(HPD)が確認された場合、死亡リスクが増加する PD(ピーディー);Progressive Disease 無病生存期間;むびょうせいぞんきかん;Diseas

Nivolumab, a monoclonal antibody to programmed cell death protein-1 (PD-1), has revolutionised the management of patients with advanced non-small cell lung cancer (NSCLC). Treatment with nivolumab is associated with toxicities known as immune-related adverse events. Although pneumonitis is a potentially serious event, little is known of its clinical and radiographic features. We here report a. Furthermore, the clinical course over almost 2 years as well as the MRI findings suggest that PD-1 inhibition may result in long-lasting tumor control following initial pseudoprogression. Funding This work was supported by a grant from the Canton of Zurich (HSM-2) Figure 1. Serial abdominal CT images showing pseudoprogression of the intestinal lesion and corresponding time point responses in the target lesion (left adrenal gland, red circle). (A) At baseline, suspicious focal wall thickening in the. Pseudoprogression on PSMA PET imaging of a mCRPC patient under anti-PD1 treatment Larissa Bastos Costa 1 & Marcelo Araujo Queiroz 1,2 & Felipe de Galiza Barbosa 1 & Rafael Fernandes Nunes 1 & PD-L1 expression Anti-PD-1/PD-L1 Time to PP Symptoms of PP Time to response (months) Subsequent treatment (time) Sarfay et al. (2016) 17 F/68 squamous NSCLC locally advanced 2 NR nivolumab 1 week Pain, sys.infla

Pseudoprogressionが約5%で認められたとのことなので、真のHPDは差し引き9%程度ということか。 単剤化学療法におけるHPDは約5%とのことだから、PD-1 / PD-L1阻害薬で2倍程度はHPDが発生したということだ Hodi et al. reported pseudoprogression with Nivolumab (anti-PD-1) treatment in about 8% of the patients examined []. With regards to Pembrolizumab (anti-PD-1), Hodi et al. demonstrated that patients with advanced malignan

Pseudoprogression With Immunotherapy Treatment for Cance

Hodi et al. reported pseudoprogression with Nivolumab (anti-PD-1) treatment in about 8% of the patients exam-ined [16]. With regards to Pembrolizumab (anti-PD-1), Hodi et al. demonstrated that patients with advanced sion (≥25 We present a case of metastatic melanoma to the brain associated with significant pseudoprogression after treatment with the PD-1 inhibitor pembrolizumab. Case Presentation A 56-year-old woman presented with BRAF V600E -mutant metastatic melanoma to subcutaneous tissues, axillae, and adrenal glands 4 years after excision of a 2.13 mm, nonulcerated primary lesion Currently, there is no established standard of care for patients with metastatic CSCC. Based on the mechanisms of CSCC carcinogenesis has been postulated that these tumors may be amenable to PD-1/PD-L1 blockade. This case illustrates a patient with CSCC with nodal involvement and pulmonary metastases, refractory to two lines of platinum-based regimens and salvage surgery, for whom treatment.

免疫療法におけるHyperprogressive disease、pseudo

免疫反応の活性化をもたらす4).抗PD-1抗体であるニボ ルマブ(nivolumab)とペムブロリズマブは,PD-1と PD-L1の結合阻害を介して抗腫瘍効果を発揮し,非小細 胞肺癌に対する標準治療の一部となったため,多くの肺 癌患者に使用 Saâda-Bouzid E, Defaucheux C, Karabajakian A, et al. Hyperprogression during anti-pd-1/PD-L1 therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol 2017;28:1605-11. [] [ PD-1/PD-L1 Pseudoprogression was first reported in CTLA-4 therapy in advanced melanoma (24 of 327 patients; 7.3%) (). It is characterized by tumor depression after rapid progression. The biopsy results show lymphocyte. The pseudoprogression analysis presented in the ASCO poster stemmed from a larger ctDNA study on more than 100 individuals, who were tested at baseline and during treatment with anti-PD-1 therapy alone or in combinatio 1. Introduction Nivolumab works as a checkpoint inhibitor by binding to the T-cell programmed death- (PD-) 1 receptors and therefore preventing the tumour cell PD-ligand 1 (PD-L1) from binding to them and inactivating the T-cell

Pseudoprogression in Patients Treated with Immunotherap

  1. PD‐1 blockade facilitated the proliferation of highly suppressive PD‐1 + effector (CD4+) T regulatory cells One of three patients with HPD had MDM2 amplification versus 0 of 18 patients without HPD Kim et al. 20 TTF <2 months or
  2. Depuis une dizaine d'années, de nouveaux traitements ont fait leur apparition : les immunothérapies. En stimulant le système immunitaire, elles aident le corps à lutter par lui-même contre le cancer. Point sur les thérapies les plus prometteuses : les anticorps anti-PD-1 et PDL-1
  3. Pseudoprogression was described for the first time as bone scan flare phenomenon in breast cancer and prostate cancer patients receiving hormone therapy or bisphosphonates [1 - 6]. In this case, it was based on the results of the first follow - up bone scintigraphy, showing increased radiotracer uptake in hot spots or even increasing their number s
  4. Anti-PD-1/PD-L1 immune checkpoint inhibitors can block PD-1 from binding with its ligands and restore the vitality of effector T cells, thus reducing the chance of immune escape (8). The proven anti-tumor effect and good tolerability of PD-L1 antibody have led to it being widely used in clinic ( 9 )
  5. Pseudoprogression has been reported for anti-CTLA-4, anti-PD-1, and anti-PD-L1 agents across multiple cancers, including melanoma, lung cancer, renal cell carcinoma, and bladder cancer (1,3)

Some patients with glioblastoma show a worsening presentation in imaging after concurrent chemoradiation, even when they receive gross total resection. Previously, we showed the feasibility of a machine learning model to predict pseudoprogression (PsPD) versus progressive disease (PD) in glioblastoma patients. The previous model was based on the dataset from two institutions (termed as the. Pseudoprogression manifesting as recurrent ascites with anti-PD-1 immunotherapy in urothelial bladder cancer Sweis R Zha Y Pass L et al. See more Journal for ImmunoTherapy of Cancer (2018) 6(1) DOI: 10.1186/s40425-018 5.

Pseudoprogression Manifesting as Recurrent Ascites with Anti-PD-1 Immunotherapy in Urothelial Bladder Cancer - Beyond the Abstract April 10, 2018 Five anti-PD-1/L1 immunotherapies have been approved for advanced/metastatic urothelial bladder cancer since 2016, which has shifted drastically the way in which patients are treated PD-1阻害剤・PD-L1阻害剤の登場は非小細胞肺がん(NSCLC)の治療に大きな進歩をもたらしたが、一部の患者では治療開始後に急速な病勢進行(Hyperprogressive disease)が起こることが報告されている。フランスGustave Roussy

腫瘍内科勉強用ブログ 抗 Pd-1/Pd-l1 抗体投与患者に生じた

18. Sweis R., Zha Y. et al. Pseudoprogression manifesting as recurrent ascites with anti-PD-1 immunotherapy in urothelial bladder cancer. Journal for ImmunoTherapy of Cancer. 2018;6:24. doi: 10.1186/s40425-018-0334-x. 19. Koll Ferrara, R., Mezquita, L., Texier, M. et al. Hyperprogressive Disease in Patients With Advanced Non-Small Cell Lung Cancer Treated With PD-1/PD-L1 Inhibitors or With Single-Agent Chemotherapy. JAMA. 2018. 4(11):1543-152 抗PD-1 抗体薬キイトルーダは、非小細胞肺癌の1次治療(最初の治療)として、従来の抗がん剤治療と比較した非盲検ランダム化比較第Ⅲ相試験(KEYNOTE-024試験)において、PD-L1高発現の患者で全生存期間(OS)を延長しまし. Programmed cell death receptor 1 (PD-1) is an inhibitory co-receptor expressed by Tcells. Binding of PD-1 with its ligands (PD-L1/PD-L2) suppresses anti-tumor responses [8, 9]. The development of monoclonal antibodies targe

医学文献検索サービス -メディカルオンライ

1. Gandini S, Massi D, Mandalà M. PD-L1 expression in Cancer patients receiving anti PD-1/PD-L1 antibodies: a systematic review and meta-analysis. Crit Rev Oncol Hematol 2016; 100:88-98. 10.1016/j.critrevonc.2016.02.001 [ Patient Characteristics and Treatment The clinical characteristics of study patients are presented in Table 1.Thirty (38.5%) and 48 (61.5%) of the CE lesions were PsPD and PD, respectively. There. PD-1 Inhibition can be Combined with IL-12 in Subjects with Recurrent Glioblastoma E. Antonio Chiocca, MD, PhD 1, Rimas V. Lukas, MD 2, Ganesh Rao, MD 3, Jill Buck 4, Nathan Demars, MS 4, Amy Smith 4, Taylor Estupinan MD/PhD student 1 point · 1 year ago The term pseudoprogression refers to an inadequacy of a test to accurately measure tumor response. In your example, a drug could increase the apparent tumor size when imaged, but the increased mass is actually due to immune cells 『頭頸部がん薬物療法ガイダンス 第2版』のMinds掲載ページです。作成方法の観点から質の高い診療ガイドラインと評価されました。監修:日本臨床腫瘍学会、編集:頭頸部がん薬物療法ガイダンス第2版作成部会、発行年月日:2018年.

PD-L1発現を認めない症例でも奏効する場合があるため,PD-L1発現は効果予測バイオマーカーとして不十分であ ると思われる. 本症例ではニボルマブ開始後に肺癌原発巣が一過性に 増大し,その後に縮小するpseudoprogressionが認め Additionally, compared with other PD-1 inhibitors, the authors suggested that a relatively low proportion of disease control following camrelizumab administration might be attributable to the poorer baseline clinical characteristics i PD-1-blocking antibody (10 mg/kg) was injected intraperitoneally 3 times on days 30, 35, and 40 or continuously injected every 5 days from day 0 to day 85 following T cell injection. n = 6-9 mice per group. *P < 0.05. Cell-intrinsic. Recent reports suggest anti-PD-1/PD-L1 agents are active in a subset of NSCLC patients with BM showing acceptable toxicity. These advances are expected to change soon the management of these patients but additiona REVIEW Open Access The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy Xueping Wang1, Fang Wang1, Mengjun Zhong1, Yosef Yarden2 and Liwu Fu1* Abstract Immune checkpoint inhibitors (ICIs), suc


抗 PD-1/PD-L1 抗体投与患者に生じた Hyperprogression に

1) An early decrease in rADC was related to better survival in GBM: this finding underlines the relevance of hypercellularity in the 1st phase of the immunotreatment 2) Modification of rCBV can be useful in distinguishin The type of ICI may impact the observed rate of pseudoprogression, with a lower rate reported in anti-PD-1/PD-L1 than in anti-CTLA-4. In a subset of patients in KEYNOTE-001 with advanced melanoma receiving pembrolizumab (anti-PD-1), the rate of pseudoprogression was 7.3%, which was lower than the observed rate in the context of ipilimumab despite using the same criteria ( 12 ) ized IgG4 programmed death 1 (PD-1) immune-checkpoint inhibitor antibody, and PD-1 is expressed on antigen-stimulated Tcells and tumor cells. Interaction of PD-1 with its ligands inhibits the antitumor activity of the cytotoxic


  1. PD with a favorable ctDNA profile (p = 0.16) Analysis of circulating tumor DNA in pseudoprogression in anti-PD1 treated metastatic melanoma Jenny H Lee 1,2,3,4, Georgina V Long 4,5,6,7, Alexander M Menzies 4,5,6,7, 4,5,6,
  2. significant pseudoprogression after treatment with the PD-1 inhibitor pembrolizumab. Case Presentation A 56-year-old woman presented with BRAFV600E-mutant meta-static melanoma to subcutaneous tissues, axillae, an
  3. Patient demographics and anti-PD-1 therapy A total of 66 patients with BM who received either pembrolizumab or nivolumab between October 2012 and March 2016 were identified. Baseline demographic.
  4. PD-1 is also a surface receptor belonging to the Ig superfamily and is expressed on T and pro-B cells and recognizes PD-L1 and PD-L2 as ligands. PD-L1 is a transmembrane protein whose binding to its receptors, PD-1 and
  5. REVIEW ARTICLE FDG PET/CT for assessing tumour response to immunotherapy Report on the EANM symposium on immune modulation and recent review of the literature Nicolas Aide1,2,3,4 & Rodney J. Hicks5,6 & Christophe Le Tourneau7,8 & Stéphanie Lheureux9 & Stefano Fanti4,10 &.
  6. development of other drugs such as PD-1 and PD-L1 in-hibitors. Currently, seven ICIs are about to be FDA-approved for a range of indications, in monotherapy or in combination with other drugs. They consist of one anti-CTLA-


  1. cells (Fig 1) (7,9,10). The PD-1 ligands PD-L1 and programmed cell death 1 ligand 2 (PD-L2) are expressed by APCs. PD-L1 is also present on normal nonhematopoietic cell membranes as well as on tumor cell membrane
  2. 文献「抗PD-1抗体投与中のpseudoprogressionを考慮した薬剤変更時期の検討」の詳細情報です。J-GLOBAL 科学技術総合リンクセンターは研究者、文献、特許などの情報をつなぐことで、異分野の知や意外な発見などを支援する新し
  3. ating pseudoprogression from true progression in patients with stage IV melanoma given PD-1 inhibitors Date: 13 Feb 2018 Author: By Shreeya Nanda, Senior medwireNews Reporter.
  4. receiving PD-1 inhibitors and showed a decrease from baseline in presence of pseudoprogression (17). Pseudoprogression seems to be associated with a high likelihood of 1-year survival compared to patient
  5. Pseudoprogression in a 65-year-old patient with lung carcinoma treated with nivolumab (anti-PD-1). Baseline axial CT showed a lung mass in the upper right lobe with normal adrenal glands. At a 38-week follow-up (FU), there was
  6. もう1つのprimary endpointである全生存期間は,中央値でプラセボ群16.1カ月,ベバシズマブ群15.7カ月,HR 1.13(95%CI:0.97—1.37,p=0.21)と有意差は認められなかった。無増悪生存期間においては,ベバシズマブの延長傾向
Immunotherapy for Metastatic Triple Negative Breast Cancer

Pseudoprogression を認めた肺腺癌の 1

Kim HK, Baek SW, Jeong Y, Yang Y, Kwon J, Han HS, An JY, Woo CG, Lee OJ, Lee TG, Lee TG, et al: Pseudoprogression presenting as intestinal perforation in non‑small cell lung cancer treated with anti‑PD‑1: A case report. Mo Regarding PD-1/PD-L1 axis development, there has been a 20-fold increase in the number of active clinical trials in the last 4 years. However, this has not been matched by patient recruitment rates, as a 70% decrease of patien A total of 294 patients (72.4%) had nonsquamous histology, and 377 (92.9%) received a PD-1 inhibitor as monotherapy in second-line therapy or later. Pseudoprogression was observed in 19 patients. Notably, the response to PD-1 inhibition, or lack thereof, does not predict for subsequent response to ipilimumab. One of the earliest studies establishing the efficacy of post-PD-1 ipilimumab was CheckMate 064. This randomize PD-1 checkpoint inhibitor therapy was subsequently shown to be PsP with a partial response at Week 36 • 59 year old male status post 1 prior line of therapy • Unifocal disease at study entry, with 1 enhancing and 1 non g 0 2 4.

Pseudoprogression manifesting as recurrent ascites with anti

Pseudoprogression manifesting as recurrent ascites with anti-PD-1 immunotherapy in urothelial bladder cancer April 9, 2018 With the widespread use of immune checkpoint therapies, varying patterns of responses and immune-related adverse events are being observed Cloughesy TF, et al.: Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. Nat Med. 2019 キイトルーダ (Keytruda)は,ペムブロリズマブ(Pembrolizumab)という抗体で,PD-1阻害剤といわれます Nivolumab is an IgG4 antibody that targets programmed death-1 protein (PD-1) on the T-cell surface. It acts by blocking T-cell interaction with programmed death ligand −1 protein (PDL-1) expressed by various cellular components in the tumor microenvironment [ 1 ], resulting in un-inhibition of T-cells and increased anti-tumor host immunity rADC cut-off value for identifying PD of > 27.05% (area under the curve 0.844±0.065, sensi-tivity 0.86, specificity 0.86, p = 0.014). Conclusion This feasibility study shows that the assessment of rADC using parametric response map Figure 1: This figure shows the mechanism of action for immune checkpoint inhibitors that target PD-1 or PD-L1. PD-L1 binds to PD-1, preventing the T cell from killing the tumor cell. Blocking PD.

Radiologic Heterogeneity in Responses to Anti–PD-1/PD-L1IL-8 levels indicate tumour response early in anti-PD-1Frontiers | Hyperprogression After Immune-Checkpoint

Delayed pseudoprogression of a vestibular schwannoma postradiosurgery. Janna Malone, David Tiberi, John Sinclair, Eduardo Gaviolli, Shawn Malone Radiosurgery (RS) can offer excellent local control in the management of both benign and malignant tumors measuring less than 3 cm in size PD-L1 is expressed in glioma cells, correlates with tumor grade, and contributes to immunoresistance. The PD-1/PD-L1 pathway plays an important role in glioma biology. The use of anti-PD-1/PD-L1 antibodies i 01 e e e e e100 Journal of Thoracic Oncology ® • Volume 10, Number 10, October 2015 A 50-year-old man with a 35-pack-year history of smok Title Central Nervous System Pseudoprogression in a Patient Treated with PD-1 Thus, PD‐1 blockade may facilitate the proliferation of highly suppressive intratumoral PD‐1+ effector Treg cells, with a FoxP3high CD45RA− CD4+ phenotype, resulting in HPD 15. Also, analysis of circulating CD8+ lymphocytes at baseline shows that lower frequency of effector/memory subsets (CD45RA−CCR7−) and higher frequency of exhausted TIGIT+ in PD1+ cells were associated with HPD 10

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